Neonatal atrial septal defect if the defect is small, the clinical manifestation is not obvious, usually is the first observation, regularly go to the hospital to review the cardiac ultrasound, the vast majority of babies’ defects can be closed on their own, usually should pay attention to feeding, to reduce choking, pay attention to the development of the child, if the clinical manifestations of the more obvious, or to the age of three years old and still can not be closed, should be considered elective surgical treatment. Atrial septal defects in newborns may be unclosed foramen ovale or primary or secondary atrial septal defects. Smaller defects can usually be closed gradually as the child grows and develops. If the defect is large, or if it has not closed by the age of three, elective surgical closure will be considered. A large atrial septal defect will affect the child’s growth and development, and may lead to recurrent respiratory infections, growth retardation, etc. In principle, surgery should be performed as soon as possible, but due to the young age of newborns, the risk of surgery is high, therefore, under the guidance of a specialized cardiologist or cardiac surgeon, should choose the appropriate time to perform surgical treatment. The existence of atrial septal defect is recommended to timely visit the cardiovascular department for treatment, according to the doctor’s requirements for regular review, is to feed the child to pay attention to strengthen nutrition, prevent choking.