Swelling ankle sprain, mainly divided into muscle injury, ligament injury and bone injury, for different degrees of injury, need to use different drugs, including painkillers, muscle relaxants, nutrient joint drugs. 1. Muscle injury: muscle injury is generally not serious, within 72 hours of the injury can be appropriate ice packs, local can be applied diclofenac sodium ointment. If muscle tightness occurs, muscle relaxants can be used, such as ethylpiperidone hydrochloride. 2. Ligament injury: ligament injury is relatively serious, you can first ice, and then through the external application of lidocaine, oral ibuprofen pain relief. 3. Bone damage: If the bone damage is large, you can apply lidocaine ointment, and then take oral painkillers such as aspirin, ibuprofen, celecoxib. If the joints are severely damaged, you can use nutritive joint medications, such as glucosamine hydrochloride and sodium vitrate. If medication fails to provide relief, immediate medical attention is required and surgical treatment should be taken if necessary. For ankle sprains, it is recommended to analyze the extent of the sprain and determine if there is a fracture as soon as possible through X-ray examination. For patients who have already suffered a fracture, simple medication is ineffective and surgery should be carried out as soon as possible. All the above medications should be chosen under the guidance of a doctor, do not use your own medication.