Premature ovarian failure refers to the depletion of ovarian follicle reserve and the gradual loss of estrogen synthesis function before the age of 40, which in turn causes a series of symptoms. Commonly used medications include sex hormone drugs, calcium and multivitamins. 1. Sex hormone drugs: Hormone replacement therapy can effectively relieve the symptoms of estrogen deficiency and atrophy of the reproductive tract, and commonly used drugs include Fenmoton and Clindamycin. Before using the drugs, some contraindications to the use of drugs should be ruled out, such as meningioma, thrombophilia, breast tumors and other diseases. 2. Calcium and multivitamins: Due to the reduction of sex hormone synthesis caused by premature ovarian failure, the bone loss in women’s body is accelerated, so some calcium supplements should be given, together with some multivitamins and vitamin D, to promote the absorption of calcium, which can prevent osteoporosis. It is recommended that patients with premature ovarian failure should be treated with medication under the guidance of a doctor as soon as possible, and not blindly use medication on their own to avoid affecting their health.