Tightness and stiffness of the muscles of the whole body may be considered to be related to excessive fatigue of the muscles of the body. Clinically, mostly seen in athletes after a long period of physical exercise, without timely relaxation and organization of the muscles, the whole body muscle tightness, stiffness and other discomforts, mostly in the muscles of the lower limbs, the athlete’s next training has a great impact, it is recommended that the training is to be gradual and orderly, do not let the muscles overworked, and some diseases can cause the whole body muscle tightness and stiffness, such as brucellosis, rabies, tetanus infections etc. It is necessary to apply antispasmodic drugs to treat the symptoms.