Side effects such as burning sensation after discontinuation of isotretinoin for topical use usually disappear in 3-7 days, and side effects such as dry skin after oral use may last for about 2 weeks before disappearing, with adverse effects on fertility lasting about 3 months to 2 years. Isotretinoin is a dermatologic medication available in softgels and gels. The soft gel capsules are used orally for the treatment of severe refractory nodular acne, especially cystic acne, and acne vulgaris when other medications have failed. The gel is used topically to treat topical acne vulgaris and pimples. Isotretinoin is a prescription medication and needs to be used under a doctor’s supervision. Common adverse reactions to isotretinoin gel include localized burning or mild to moderate irritation, and redness or peeling in some patients. Side effects that occur with topical medications usually go away about 3 days after discontinuing the medication. Adverse effects of orally administered drugs include dryness of the mouth and lips as well as the skin, labial inflammation, conjunctivitis, optic papilla edema, thinning of the hair, weight loss, palpitations, dizziness, headache, and thrombocytopenia. Side effects usually disappear in 3-7 days after stopping the medication, and severe side effects may last for about 2 weeks before disappearing. It is important to note that Isotretinoin may cause fetal malformations. Therefore, it is recommended that women of childbearing age or their spouses should use effective contraception 3 months prior to initiating treatment with Isotretinoin, during the treatment period, and for 2 years after discontinuation of the drug. How long it takes for the side effects of isotretinoin to disappear after discontinuation of the drug has some individual differences, and monitoring should be strengthened during the treatment with this drug, so that the side effects can be found and the drug can be adjusted in a timely manner.