Diseases that cause toothache can be broadly divided into bacterial infection and other causes, bacterial infection caused by toothache can use stomatological treatment combined with cephalosporin drugs and other anti-infective, non-bacterial infections caused by toothache, such as dentin allergy, need to carry out desensitization treatment. 1. Diseases caused by bacterial infection: toothache caused by apical periodontitis can be treated with cephalosporins, such as cefazolin, cefuroxime, etc., which has a wide antimicrobial spectrum and strong antimicrobial effect, and with root canal treatment, it can alleviate the symptoms of tooth pain. 2. Diseases not caused by bacterial infection: such as dentin allergy caused by toothache, the use of cephalosporins can not alleviate the pain, desensitization treatment should be carried out. Drugs should be used under the guidance of a doctor, there may be other causes of tooth pain, it is recommended to go to the hospital, clear the cause of the disease for targeted treatment.