Weak positivity of anti-Ro52 antibody (Ro-52) is not disease-specific, and the antibody can be detected in viral hepatitis, systemic sclerosis, primary biliary cirrhosis, autoimmune hepatitis and other diseases.
1. Viral hepatitis: the clinical manifestations of hepatitis caused by different viral infections vary greatly, take the most common hepatitis B virus (HBV) as an example, the symptoms of acute stage are fatigue, anorexia, pain in the liver area, and most of the chronic hepatitis are non-specific symptoms, such as abdominal distension, pain in the right upper abdomen, and chronic hepatitis, if it continues to progress, can be developed into cirrhosis, with symptoms related to portal hypertension.
2. Systemic sclerosis: it can involve heart, lungs, kidneys and other organs, and the skin is the hallmark lesion. Typical clinical manifestations are swelling, thickening and sclerosis of fingers and facial skin, and atrophy of skin in the later stage.
3. Primary biliary cirrhosis (PBC): the clinical manifestations of PBC vary according to the course of the disease. Early stage of PBC has no obvious symptoms, and there may only be serological manifestations of cholestasis and positive antimitochondrial antibody (AMA), with the progress of the disease, abdominal discomfort, itching, fatigue, and bone pain and other symptoms appear.
4. Autoimmune hepatitis (AIH): AIH patients are asymptomatic in mild cases, but when the disease is active, there are symptoms such as malaise, abdominal distension, lack of appetite, itching and jaundice.
Weak positivity of anti-Ro52 antibody (Ro-52) suggests the possibility of the above and other diseases, and it is recommended to go to the hospital for further examination.