Later stages of glioblastoma can be so severe that it affects the cerebrospinal fluid circulation, and symptoms such as visual impairment, sensory disturbances, coma, and even life-threatening conditions can occur. Glioblastoma belongs to a malignant tumor disease originating from glial cells in the brain. The disease progresses at a rapid rate and has a poor prognosis. Glioblastoma may affect the cerebrospinal fluid circulation disorder in the later stage, forming obstructive hydrocephalus, and the patient may also have visual impairment such as loss of vision and visual field loss, as well as hearing loss and somatosensory loss. Secondly, in the late stage of glioblastoma, patients may also suffer from incontinence, coma, hemiplegia and other symptoms, which may threaten their lives when the condition continues to worsen. Since glioblastoma is a highly deteriorating tumor, patients need to actively cooperate with doctors to take a series of treatment measures such as medication, surgery and radiotherapy. When a patient is diagnosed with glioblastoma, he or she should go to the hospital in time and take active treatment under the guidance of the doctor to avoid delaying his or her condition.