There is no guarantee that a stone in the lower calyx of the kidney will be okay in the long run. Inferior calyceal stones are one of the types of kidney stones that indicate that the stone lesion is located in the inferior calyceal area of the kidney. While it is true that in the case of smaller stones, the lower calyces do not cause unusual symptoms and can be dealt with by watching and waiting, it does not mean that the patient will be fine in the long run. In the process of the development of infrarenal calyx stones, the volume of the stone lesion is likely to increase, so we can not rule out the case of hydronephrosis, and the long-term existence of the stone is likely to lead to the stimulation of the surrounding tissues, triggering infectious lesions. Hydronephrosis and kidney infection will have a direct negative impact on the functional health of the kidneys, causing symptoms such as low back pain, hematuria, fever and so on. All in all, individuals who suffer from infrarenal calyceal stones should actively cooperate with their doctors for intervention and treatment, thus the progression of the condition is likely to bring about some unusual damages, and no one can guarantee that infrarenal calyceal stones will be fine in the long run.