The main precautions for oral azithromycin are as follows: 1. Azithromycin is mainly cleared by the liver, so patients with impaired liver function should use azithromycin with caution. 2. Azithromycin can be taken before or after meals, and food does not affect the efficacy of azithromycin. 3. Azithromycin should not be taken at the same time with antacids containing aluminum and magnesium during the course of taking azithromycin. 4. The use of azithromycin for a long time may increase bacterial resistance, resulting in the inability of azithromycin or other antibacterial drugs to treat these resistant bacteria.