There are physiological factors such as long-term sedentary or lying down for a long time leading to muscle degradation, or pathologic factors such as hypokalemia, hypothyroidism, myasthenia gravis and so on. 1. Physiological factors: mainly long-term sedentary or lying down for a long time, calf muscle lack of exercise without strength. 2. Pathological factors: mainly related to endocrine diseases or neurological diseases such as hypokalemia, hyponatremia, hyperglycemia, hypothyroidism, long-term use of diuretics, myasthenia gravis, myositis, cerebral ischemia, lower limb arterial occlusion and so on. Combined with the patient’s own other symptoms, it is recommended to further diagnosis and treatment in the relevant departments. Generally speaking, after excluding physiological factors, it is recommended to consult a doctor in a timely manner to clarify the cause of the disease and treat the symptoms.