The ingredient of Lotensin is Benadryl, an angiotensin-converting enzyme inhibitor, which is a first-line long-acting antihypertensive drug, and the antihypertensive effect of this drug is very good. It is a first-line long-acting antihypertensive drug, and its adverse reactions are relatively rare in actual clinical practice. Relatively speaking, the more likely adverse reaction is a persistent dry cough, but this adverse reaction, often after discontinuing the drug, the dry cough symptoms will gradually disappear to relieve. If necessary, alternative treatment with sartans can be applied, for example, Irbesartan and Telmisartan can be used to replace it. This drug not only lowers the patient’s blood pressure, but also helps to reduce proteinuria, prevent left ventricular remodeling, and improve myocardial ischemia. It is a secondary prevention drug for patients with heart failure, as well as angina pectoris. However, this drug is not recommended if the patient’s creatinine level exceeds 3 mg/dL or if hyperkalemia is present.