High total cholesterol generally refers to the problem of hyperlipidemia, which is a decrease in a person’s lipid metabolism. Total cholesterol is the sum of cholesterol contained in all lipoproteins in the blood, including triglycerides, LDL and HDL. The total cholesterol level in the human body mainly depends on genetic factors and lifestyle, and the causes of high total cholesterol include disease factors and non-disease factors. Disease factors include cardiovascular and cerebrovascular diseases caused by atherosclerosis, various hyperlipoproteinemia, cholestatic jaundice, hypothyroidism, lipoid nephropathy, nephrotic syndrome, diabetes mellitus, pancreatic diseases and other primary diseases. Non-disease factors include eating foods high in cholesterol, obese and overweight people, as well as people who smoke for a long time, drink a lot of alcohol, suffer from mental stress, and take certain medications such as glucocorticoids and aspirin. The causes of high total cholesterol are different and different treatments are needed, including dietary treatment, medication and surgery. People who are overweight should control the total calorie intake of their diet and increase the amount of exercise, etc.