Acid reflux heartburn hiccups belong to the common symptoms of the digestive system, common in peptic ulcer, gastroesophageal reflux, etc., commonly used drugs such as omeprazole, famotidine, mosapride. 1. Peptic ulcer: its treatment includes inhibiting gastric acid secretion, protecting gastric mucosa and eradicating Helicobacter pylori. Proton pump inhibitors can control symptoms and promote ulcer healing within 2-3 days. Commonly used drugs include omeprazole and lansoprazole, etc. Adverse effects include diarrhea and bloating. Bismuth potassium citrate can cover the surface of ulcers, block gastric acid and protect gastric mucosa, adverse reactions include constipation and dry mouth. Eradication of H. pylori is done by quadruple therapy, including two antibiotics, a proton pump inhibitor, and a bismuth agent, such as amoxicillin, clarithromycin, rabeprazole, and bismuth potassium citrate. Common adverse effects of taking quadruple therapy include bloating, diarrhea, constipation, and loss of appetite. 2. Gastroesophageal reflux (GERD): its medication is acid-suppressing drugs and drugs to promote gastrointestinal dynamics. Acid-suppressing drugs are the main measures for the treatment of this disease, and the commonly used drugs are omeprazole, famotidine and so on. Promote gastrointestinal power drugs can promote gastric emptying, reduce gastroduodenal contents reflux. Commonly used drugs are domperidone, mosapride and so on. The main adverse reactions are diarrhea, abdominal pain and dry mouth. With symptoms such as acid reflux, heartburn and hiccups, it is recommended to go to the gastroenterology department of a regular hospital, under the guidance of a professional doctor, to avoid taking medication on their own.