You usually do not lose weight after thyroid nodule removal. However, if the dose of levothyroxine sodium tablets is too high, there is a risk of weight loss, thinning, and other side effects of the medication. Thyroid nodule is a kind of confined lump in normal thyroid tissue. Regular review is sufficient for benign thyroid nodules with no symptoms and normal thyroid function, but surgical resection should be considered for thyroid nodules with pressure symptoms or malignant ones, and hypothyroidism may occur after the removal of thyroid nodules. The presence of hypothyroidism may cause weight gain, and at this time it is necessary to take levothyroxine sodium tablets for treatment to maintain thyroid hormone levels within the normal range. However, if the dosage of the medication is too high, side effects of the medication such as weight loss and thinning may occur. Patients who need to undergo thyroid nodule removal should be treated under a doctor’s supervision and undergo regular review after the operation.