Understanding mastocytosis Mastocytosis is one of the common and frequent diseases in adult women, mostly seen in women aged 25 to 45 years old, and is an abnormal hyperplastic disease of breast tissue. The essence of mastocytosis is a disorder of breast structure caused by female endocrine disorder – that is, an absolute or relative increase in estrogen and an absolute or relative decrease in progesterone. Therefore it is neither a tumor nor an inflammatory disease. Patients with mastocytosis are characterized by breast pain and lumps, which are usually worse during premenstruation or emotional changes and lessen after menstruation. The size and texture of breast lumps change cyclically with menstrual flow. Before menstruation, the lumps increase in size and have a hard texture; after menstruation, the lumps decrease in size and have a tough but not hard texture, and when touched, the lumps are in the shape of nodules of different sizes with poorly defined boundaries with the surrounding tissue. Yang Xuewei, Breast Surgery Department, The Second Hospital of Harbin Medical University Why is mammary gland hyperplasia related to endocrine disorders The causes of mammary gland hyperplasia in women are now mostly thought to be related to endocrine disorders and mental factors. The external environment, work and living conditions, interpersonal relationships, and neuropsychological factors caused by various stresses can change the internal environment of the human body, thus affecting the function of the endocrine system and causing abnormalities in the secretion of one or several hormones. The mental stress of modern people is generally very high, and women are faced with work, interpersonal relationships, family and other conditions full of changes, some women have endocrine disorders, plant nerve disorders, poor sleep and irritability caused by mental factors, all of which can have adverse effects on the breast. Breast pain and breast disease Breast pain is the most common symptom of breast disease, and many breast diseases manifest as breast pain in the early stages. According to its nature, time of occurrence and accompanying signs, the most common causes are: 1, acute infection of the breast: its pain is mostly sudden, persistent and severe, accompanied by obvious tenderness and skin redness and swelling, increased body temperature, etc. 2, breast enlargement: the pain is characterized by regular appearance according to the menstrual cycle, and the nature of the pain is distension or pins and needles. 3.Breast cyst: Irregular and persistent swelling pain with mild pressure pain. 4.Breast cancer: Generally there is no obvious pain, sometimes there is an intermittent, sharp stabbing pain from inside the breast, which does not involve the external parts of the breast. If this pain occurs, you should check carefully for breast lumps in order to exclude breast cancer. Breast lumps and breast cancer When a fixed lump is found in the breast, some women may think it is a growth. In fact, breast lumps are seen in a variety of breast diseases, such as mastopexy, fibroadenoma, cumulus cyst, lipoma, and of course, breast cancer. Therefore, once you find a breast lump, you should go to the hospital for a systematic examination as soon as possible to get a clear diagnosis and reasonable treatment. The most effective prevention method is still to have regular medical checkups. Although diseases like mastocytosis are not malignant tumors, regular medical checkups can give you a clear understanding of the potential for disease in the body, and that some diseases are caused by a series of problems in body functions. For example, mastopexy is generally caused by endocrine disorders, and when you find yourself with mastopexy, it means that your endocrine disorder has begun, and endocrine disorders can also cause other diseases, such as fibroids and infertility, which must cause women to be highly alert.