Frequent consumption of cetirizine agent may impair kidney function, which is a second-generation antihistamine drug, compared with the first-generation drug, its kidney damage has been much smaller. However, if patients apply this drug in large doses for a long time, there may still be some side effects on kidney function. Especially if the patient’s kidney function is not very good, large doses of this drug, the possibility of side effects will increase a lot. Clinically, this drug is mainly metabolized by the kidneys and liver, long-term application of this drug will cause a greater burden on the kidneys, once the metabolism capacity of the kidneys is exceeded, it is possible to induce renal function damage. If applied for a long time, this damage may be irreversible. Therefore, if the clinical patients are used for a long time, it is best to take blood regularly to check the renal function indicators, according to the indicators of the situation to increase or reduce the amount of drug application, not long-term application. In addition to renal impairment, some patients may experience sedation, dry mouth, drowsiness, and even mild cardiac toxicity after using this drug.