Poor liver and gallbladder detoxification may involve a lesion in the liver and gallbladder that affects the metabolic and detoxification functions of the liver. At this time, the lesion can be clarified by examination, including liver function, contractile and diastolic function of the gallbladder, and imaging of the liver and gallbladder. If a medical disease of the hepatobiliary duct is considered, including hepatitis and biliary tract infection, antiviral and anti-inflammatory treatments are needed to relieve the hepatobiliary symptoms and restore the normal function of the liver and gallbladder. If hepatobiliary surgical lesions are considered, including hepatobiliary tumors and stones, surgical treatment is needed to remove the lesions and restore liver function. Therefore, specific analysis should be made for specific causes. Usually, attention should be paid to monitoring liver and gallbladder functions, trying to eat a regular diet, more fruits and a light diet to ensure normal liver and gallbladder metabolism and detoxification functions.