The normal reference range of serum s100b protein detected clinically by ELISA is (0.068~0.728) μg/L. The normal reference range of serum s100b protein detected clinically by ELISA is (0.068~0.728) μg/L. However, the reference value may be different for different testing methods and different hospitals, and the actual test is also needed to prevail. s100b protein is a serum marker that can reflect brain injury, generally seen in subarachnoid hemorrhage, central nervous system infections, brain tumors, spinal cord compression, cerebral vasospasm and other diseases, but the elevation of this marker alone can not be a definitive diagnosis, it must be combined with the patient’s clinical manifestations and then further examination. Therefore, when it is found to be elevated, it is necessary to seek professional help from a doctor. To summarize, the normal range of serum s100b protein is (0.068~0.728) μg/L, when it is elevated, please consult a doctor in time.