Elevated blood creatinine can be lowered, elevated blood creatinine is common in acute and chronic renal insufficiency. If it occurs in acute renal insufficiency, the cause of the disease needs to be clarified, and the cause of the disease should be treated first. If accompanied by decreased urine output or other serious complications, renal replacement therapy can be performed, such as hemodialysis, continuous blood purification therapy can reduce blood creatinine. If the elevated blood creatinine occurs in chronic renal insufficiency, the blood creatinine can be lowered by drug treatment or renal replacement therapy. The common medication is mainly kidney protection and detoxification drugs, which can be Jinshuibao, urethane, Bailing capsule, etc. The renal replacement therapy also includes hemodialysis, hemodialysis filtration, hemodiafiltration, hemoperfusion, plasma replacement and other methods.