Early pregnancy coitus may lead to preeclampsia, and the cause of biochemical pregnancy is mainly the woman’s factor, the embryo factor and the man’s factor, early pregnancy coitus is generally not related to biochemical pregnancy. Early pregnancy due to the embryo has just landed, the development is not stable, at this time coitus may lead to uterine contraction, thus leading to the occurrence of preterm abortion. The causes of biochemical pregnancy are mainly female causes, such as advanced age, polycystic ovary syndrome, luteal insufficiency, etc., embryo causes, such as chromosomal abnormalities in the embryo, and male factors, such as poor sperm quality and chromosomal abnormalities in the sperm. Therefore, coitus at the beginning of pregnancy may affect the embryo’s implantation, but it generally does not lead to biochemical pregnancy, so coitus at the beginning of pregnancy will not cause biochemical pregnancy. When physical discomfort occurs, it is necessary to actively carry out diagnosis and treatment.