The majority of patients may experience nausea, vomiting, fullness and other discomfort, often accompanied by nervousness, anxiety and fear. The cost of general gastroscopy is low. Painless gastroscopy is a combination of regular gastroscopy with intravenous injections of isoproterenol, fentanyl and lidocaine. Since fentanyl and isoproterenol have sedative and analgesic effects, and they are fast-acting, fast-recovery, short half-life, controllable, and no accumulation in the body, patients quickly enter into snoring sleep during gastroscopy, and the cricopharyngeal muscles are more relaxed, which helps gastroscopy advance. Painless gastroscopy is relatively expensive. Overall, there are advantages and disadvantages to both regular and painless gastroscopy, and it is up to your doctor to decide which modality to choose based on your actual situation.