A painful buttock pimple may be a boil or carbuncle due to a bacterial infection, or a perianal abscess if the bag is large. Medication and surgery may be prescribed. 1. Boil: If the pimple is small and the pain is not obvious, it may be a boil. You should keep the local skin clean and dry and avoid sitting for a long time. It can be treated with topical mupirocin cream. 2. Carbuncle: If the pimple is large, red and swollen, can obviously feel the fluctuating sensation, and even accompanied by systemic symptoms, such as fever, etc., it may be caused by more serious bacterial infection. It is recommended that patients seek medical treatment in time for sterilization and incision to drain pus, if not yet mature, can be applied with ichthyol ointment. If accompanied by systemic symptoms, antibacterial drugs such as cefuroxime, azithromycin, etc. can be taken. 3. Perianal abscess: If the abscess is large, painful and obvious, and grows around the anus, it may be a perianal abscess. Need to use more than two generations of cephalosporin antibiotics, such as cefazolin, and with metronidazole and other anti-anaerobic drugs treatment, if necessary, incision and drainage. It is recommended that patients keep clean and hygienic at the same time close observation, if there is no improvement, it is recommended to consult a doctor for a clear diagnosis, and targeted treatment.