A transaminase value of more than 900 indicates the presence of significant hepatocellular damage, which requires prompt clinical treatment, but the condition is not necessarily very serious. First of all, in patients with cholecystitis and cholangitis, the acute phase may cause a rapid increase in aminotransferase values, which may even reach more than 900 or more than 1,000. At this time, it may only be localized hepatocellular damage, if the application of antibacterial drugs can quickly control the inflammation, and at the same time give the liver enzyme-lowering drugs after application. The transaminases may decrease rapidly and even return to the normal range. Secondly, for patients with chronic liver disease, if there is a significant increase in aminotransferases, it means that the overall function of the liver is progressively aggravated and deteriorated. If it continues to rise, liver insufficiency and liver failure may occur, leading to the occurrence of serious complications such as hepatic encephalopathy and upper gastrointestinal bleeding, and even causing the death of the patient in a short period of time. In this case, simply applying liver-protecting and enzyme-lowering drugs, artificial liver or even liver transplantation may be needed to save the patient’s life.