Fungal sinusitis is mainly treated by surgery, and for those who need systemic antifungal therapy, antifungal drugs such as itraconazole are usually taken orally. The presence of allergic factors causing disease, oral prednisone and other glucocorticosteroids to assist in the treatment. The specific medication needs to be decided according to the specific condition, there is no comparison of which oral medication is better. As fungal sinusitis caused by fungal infection, some cases need oral ketoconazole, itraconazole, amphotericin B and other antifungal drugs; allergic fungal sinusitis patients can take oral prednisone and other glucocorticosteroids can relieve the symptoms of rhinitis is an important adjunctive treatment. The choice of medication for fungal sinusitis needs to be standardized after systematic examination and clear diagnosis by a specialist.