After treatment, the five-year survival rate of gastric sinus adenocarcinoma with low differentiation varies from 10% to 90%, which needs to be analyzed with specific conditions. Gastric sinus adenocarcinoma is a malignant tumor of digestive system caused by heredity, bad dietary habits and other factors. Hypofractionated adenocarcinoma means that the cancer cells are poorly differentiated, with higher degree of malignancy and poorer prognosis. After diagnosis, the main treatment is comprehensive treatment mainly based on surgical resection, and the specific prognosis is more related to the stage. After active treatment, the five-year survival rate of gastric sinus adenocarcinoma in early stage is about 90%; in middle stage, it is about 50%~60%; in late stage, it is only about 10%. In conclusion, the later the stage is, the more complicated the condition is, and the worse the prognosis is. Patients need to pay attention to the regular review as prescribed by doctors in order to reduce the recurrence.