What anti-inflammatory drugs to take for toothache is based on the characteristics of the oral flora. The preferred anti-inflammatory drug is cephalosporins, such as cefadroxil followed by nitroimidazoles, such as metronidazole and ornidazole. If the patient has a history of alcohol consumption or allergy to the use of cephalosporins within a week, cephalosporins cannot be used, and nitroimidazoles also produce a disulfiram reaction with alcohol, which can then be replaced with erythromycin. Because the local blood supply to the teeth is low, the effect of using anti-inflammatory drugs alone is limited, if you want to improve the effectiveness, you need to cooperate with local treatment. For example, pulpitis requires pulpotomy, pericoronitis requires local rinsing and medication, gingivitis and periodontitis require local cleaning with rinsing and medication, periapicalitis and periapical abscess may require abscess incision and drainage, and these local treatments with anti-inflammatory drugs are more effective.