Two prednisone tablets a day belongs to the common dosage of administration, if long-term use of the possible hazards of peptic ulcer, Cushing’s syndrome, diabetes, infections and so on. Prednisone belongs to the glucocorticoid class of drugs, with anti-inflammatory, anti-allergy, anti-rheumatic effect, can be widely used in the treatment of allergic and autoimmune diseases, 5mg/tablet specifications of the prednisone tablets 2 tablets per day belong to the common dosage. The possible hazards of long-term use of prednisone include peptic ulcers, Cushing’s-like syndrome, diabetes, and infections. Patients with contraindications to Prednisone medication such as hypertension, glaucoma, psychosis, gastric and duodenal ulcers and allergy to the components of the drug should not be treated with this drug. Note that the drug is used with caution in tuberculosis, acute bacterial or viral infections. When necessary to apply, appropriate anti-infective treatment must be given. After long-term use of the drug, the dosage should be gradually reduced before stopping the drug. Use with caution in diabetes mellitus, osteoporosis, cirrhosis, renal dysfunction, hypothyroidism. For those with bacterial, fungal, or viral infections, it should be used with caution along with the application of adequate amounts of sensitive antibiotics. Prednisone should be used under the guidance of a physician, and it is recommended that patients who need to use this drug for treatment go to the relevant departments of regular hospitals for detailed consultation.