Decreased serum copper oxidase absorbance is an important manifestation of mental disorders associated with hepatomegaly. Autosomal recessive monogenic disorders have a positive family history in about 20% to 30% of the population most of which develop in the sibling generation. At least 25 mutations in the gene, localized to chromosome 13, have been identified, and it has not been determined whether the defects are structural or control genes, although a higher incidence in consanguineous marriages has been reported in the literature. What are the preventive methods for mental disorders associated with hepatomegaly? 1, avoid consanguineous marriage, the implementation of eugenic protection law, all should avoid childbirth. 2, many patients with hepatomegaly nuclear degeneration after formal copper, symptomatic treatment, clinical signs and symptoms improved significantly, but after discharge from the hospital patients think that the symptoms have disappeared, and do not take medication or less than the prescribed dose of medication, but also do not pay attention to avoid taking food containing high copper content, the result is that the condition aggravated and re-admitted to the hospital, and even left the world as a result of this, the patients and their family members on the treatment of the compliance of the good condition is often in long-term remission, a better quality of life, and even a better quality of life. The patients and their family members with good compliance to the treatment often have long-term remission of the disease, have a better quality of life, and even in the academic, career to make good results. 3, patients with hepatomegaly are more common anxiety and depression, due to slurred speech, clumsy movements, liver function impairment and other symptoms, the disappointment of the future; to cause the family economy, manpower and material resources and other burdens and feel guilty, depressed, unwilling to cooperate with the diagnosis and treatment, or even refused to treat, family members, relatives, friends, etc. to the patient’s economic, material and spiritual support and encouragement, can often enhance the patient’s confidence in overcoming the disease, the patient’s confidence in overcoming the disease. Family members, relatives, friends and other patients on the economic, material and spiritual support and encouragement, often to enhance the patient’s confidence in overcoming the disease; on the patient’s life care and nursing, often to enhance the effect of its treatment. 4.Schools, units, medical insurance and administrative departments, and even charitable organizations, financial support for patients and their families, can solve some of his (her) difficulties, reduce or remove their worries, but also help patients get a good prognosis.