Menopause at the age of 45 is a normal phenomenon. The normal age of menopause for women is 45-55 years old, the earliest is not earlier than 40 years old and the latest is not later than 55 years old, menopause at this age is a normal phenomenon. Whether or not appropriate treatment is needed during menopause depends on whether or not appropriate perimenopausal symptoms occur. Hormone replacement therapy should be considered if there are significant hot flashes, sweating, irritability, insomnia, and significant bone loss, as well as significant cardiovascular complications due to atherosclerosis, which affect daily life. If the uterus is present, estrogen and progesterone replacement therapy is given, and if the uterus has been removed, estrogen replacement therapy alone is given.