A common typical symptom of rheumatoid arthritis is morning stiffness, i.e., swelling of the relevant target joints of both hands increases in the morning, affecting the patient’s ability to make a fist and move his or her fingers. The swelling usually lasts for more than an hour, then gradually subsides and is repeated the next morning. Rheumatoid affects primarily the small proximal joints of the patient’s hands and is symmetrical. Typically, the wrist, metacarpophalangeal, and interphalangeal joints are the target joints of rheumatoid arthritis. In addition, rheumatoid may also affect large joints, such as the knee, ankle, and shoulder joints.