The formation of blisters is mostly the result of inflammatory reactions, such as those caused by bacteria, viruses, parasites (scabies) or allergic reactions, commonly aspergillosis, herpes-like dermatitis, herpes zoster, etc. Other etiologies such as basal cell liquefaction and basement membrane lesions, ballooning degeneration and reticular degeneration, epidermal necrolysis and epidermal peeling due to drugs and Staphylococcus aureus infection are seen in macrocancerous epidermolysis bullosa drug rash and Staphylococcus aureus scald-like syndrome. With the advent of summer, some of the skin is exposed and people may be scalded by boiling water, oil, chemicals, etc. if they are not careful. To deal with blisters after burns, first drain the water from the blisters at a low level, and then rinse the wound with natural water for more than half an hour. After a burn, one should use a sterilized pinhole, scissors, etc., to poke the blister from the low side of the blister and release the water inside, because the blister is rich in inflammatory substances that can easily cause infection. However, when draining the blisters, be careful not to cut the skin outside the blisters, because the intact skin is the body’s barrier against bacterial invasion, and once it is cut, the bacteria will quickly invade and infection will occur. The skin lesions of herpes zoster are characterized by large blisters on normal-looking skin and mucous membranes with peeling epidermis, which occur in the folds of the skin, mostly in middle-aged people. Herpes-like dermatitis, and herpes zoster are polymorphic lesions.