Renal tubular atrophy needs to be treated according to the specific etiology, such as hypertension caused by the need to control blood pressure and protect the kidneys; such as glomerulonephritis caused by the perfect renal puncture biopsy, to clarify the type of pathology, and comply with the doctor’s instructions to use medication (prednisone acetate, tacrolimus, etc.). 1. Hypertension: If it belongs to bilateral renal atrophy, it is generally common in hypertensive renal damage, which requires active control of blood pressure, protection of kidneys and reduction of urinary protein, and antihypertensive drugs can be taken under the guidance of physicians, such as calcium antagonists, nifedipine extended-release tablets, and felodipine, and β-blockers, such as metoprolol and sotalol hydrochloride. 2. Glomerulonephritis: this disease can cause renal tubular atrophy, if necessary, need to improve the renal puncture biopsy, clear pathology, can follow the doctor’s instructions to apply glucocorticoids (prednisone acetate) or (and) immunosuppressive drugs (tacrolimus). It is recommended that patients with renal tubular atrophy consult a regular hospital in a timely manner, complete the relevant examinations, clarify the cause of the disease and carry out targeted treatment.