There are many causes of congenital heart disease, and current medical research suggests that it may be related to the health and nutritional status of the mother during pregnancy, such as: ① Viral infections such as rubella, mumps, and influenza in the mother’s first 3 months of pregnancy (especially from 3 weeks to 8 weeks of pregnancy) may affect the development of the fetus’ heart and large blood vessels, forming congenital heart disease or combined with malformations in other areas at the same time. Environmental factors around the fetus, such as amniotic membrane lesions, mechanical compression around the fetus, maternal nutritional disorders, vitamin deficiencies, etc., may be associated with the development of congenital heart disease. ②Mothers suffering from endocrine diseases during pregnancy; receiving radiation exposure; other drugs (e.g., antibiotics such as tetracycline, oxytetracycline, streptomycin and hormonal drugs such as danazol and vinblastine), and the effects of toxic substances (e.g., formaldehyde) may also cause fetal cardiovascular malformations. ③ The environment of the lack of oxygen in the plateau area. For example, the incidence of congenital heart disease in highland areas such as Yunnan and Tibet is significantly higher than that in plain areas. ④Family and genetic factors, etc., may also be the cause of the occurrence. Although congenital heart disease is not a hereditary disease, there is a hereditary tendency, and it is not uncommon for families with siblings suffering from congenital heart disease at the same time or parents and children suffering from congenital heart disease at the same time, and the nature of the disease is very similar. ⑤ Parents’ bad habits. Maternal alcoholism, smoking, or “passive smoking” can increase the incidence of precocious heart disease in infants. The prevalence of prediabetes in infants born to mothers who smoke is twice as high as that of nonsmoking mothers.