Tuberculous pleurisy has been taking more than 2 years of drugs, such as the condition has been bad, may be the occurrence of drug resistance, combined with other infections, poor disease control, etc., according to the cause of the appropriate adjustment of the amount of drugs or timely replacement of medication, the use of drugs in accordance with medical advice. 1. Drug resistance: patients need to take isoniazid, rifampicin and other anti-tuberculosis drugs for a long time, if the drug-resistant reaction to the drug, unable to control the disease, easy to recur, can be replaced with other anti-tuberculosis drugs, such as streptomycin. 2. Combination of other infections: tuberculosis pleurisy is mainly related to the infection of tuberculosis bacillus, such as bacterial infections during the disease, the effect of simple taking anti-tuberculosis drugs is not good, you need to combine antibiotics, such as cefprozil and so on. 3. Poor control: some tuberculous pleurisy is more serious, the effect of long-term medication is not good, need to change other treatment methods, such as intrapleural injection of drugs, can effectively prevent the formation of effusion, the condition of the serious, such as the combination of pleural effusion, need to do in time for the drainage of the thoracocentesis. If tuberculous pleurisy has been taking drugs for more than 2 years, it is recommended to go to the hospital regularly for review, and find that the condition has been controlled, can be discontinued under the guidance of the physician, and should not increase the dosage or increase the duration of the medication without authorization.