Kidney damage can be avoided by keeping lupus erythematosus under control, but if chronic kidney damage has occurred before, it cannot be reversed, and further impairment of kidney function may occur as the burden on the kidneys increases. Lupus erythematosus is an autoimmune connective tissue disease caused by the presence of high levels of auto-antibodies and immune conjugates in the body, leading to tissue damage. If lupus erythematosus damages the kidneys, hematuria, proteinuria, elevated creatinine, increased urea nitrogen, and uremia may occur. If chronic kidney disease occurs, the condition will further deteriorate and there is no way that it can be cured completely. Patients with lupus erythematosus are prone to kidney damage. Kidney tissue examination can help confirm the diagnosis of lupus kidney damage, and renal failure is one of the major causes of death in lupus erythematosus. If lupus erythematosus involves the kidneys and enters the chronic kidney disease stage, kidney function may also be impaired as the burden on the kidneys increases due to medications, infections and other factors. Therefore, patients with lupus erythematosus should go to the hospital for examination as soon as possible, and should actively cooperate with doctors for treatment after diagnosis.