Aspirin should not be taken with other NSAIDs, anticoagulants, digitalis and other drugs. 1. NSAIDs: Aspirin should not be taken with other salicylic acid-containing NSAIDs (ibuprofen, rofecoxib, celecoxib, etc.), which increase the risk of gastrointestinal ulcers and gastrointestinal bleeding. Ibuprofen interferes with the irreversible inhibitory effect of aspirin on platelets. 2. Anticoagulants: coumarin derivatives/heparin/warfarin (vinblastine, adipex sodium, warfarin sodium), etc., the combination of which increases the risk of bleeding and should be used with extreme caution. 3. Digitalis drugs: Aspirin and digitalis (digoxin), if used in combination, there is a reduction in the ability of the kidneys to clear digoxin, resulting in a rise in the blood concentration of digoxin, which can easily lead to digoxin poisoning. If it must be used, blood concentration needs to be strictly monitored to avoid serious consequences. 4. Others: anti-gout drugs that promote uric acid excretion (probenecid, benzosulfazone), hypoglycemic drugs (insulin, sulfonylureas), glucocorticoids, diuretics, methotrexate, etc. should not be combined with aspirin. Aspirin is contraindicated in people who are allergic to the drug, have a tendency to bleed, and have recently undergone surgery; adverse reactions are skin rashes and gastrointestinal bleeding. Aspirin and other drug interactions are more complex, such as the need for joint use must be used under the guidance of clinicians to avoid adverse effects.