Sore and swollen knees after running need general treatment, medication, physical therapy and surgery according to the cause, etc. Common causes include excessive exercise, meniscus injury, synovitis, lumbar disc herniation and so on. 1. Excessive exercise: knee soreness and swelling after running is common in people who usually exercise less and have inflammatory reactions such as soreness and swelling after excessive exercise. In this case, generally do not need treatment, after sufficient rest, soreness can be relieved. Usually pay attention to do a good warm-up before exercise, avoid sudden strenuous exercise. 2. meniscus injury: acute stage of the injury, you can choose ice packs to help reduce the pain and swelling of the knee joint, while paying attention to rest and braking, you can also use ibuprofen, aspirin and other non-steroidal anti-inflammatory drugs, conservative treatment is ineffective, may need to consider surgical treatment, such as meniscectomy and so on. 3. Synovitis: first of all, bed rest is needed, with celecoxib, etoricoxib and other medications, caused by infection, but also can choose the appropriate anti-infection drugs for treatment. If there is joint effusion, puncture treatment is also available. In addition, infrared rays, ultra-short wave and other physical therapy can also be used. 4. Lumbar disc herniation: generally need bed rest, can take ibuprofen and other non-steroidal anti-inflammatory drugs to improve the symptoms, and if necessary, can receive surgical treatment, such as minimally invasive nucleus pulposus removal surgery. There are other causes of knee soreness after running, if the soreness cannot be relieved or worsens after resting, it is recommended to consult a doctor in time, complete the examination to clarify the diagnosis, and then follow the doctor’s instructions to receive the appropriate treatment. The above medications should be used under the guidance of a doctor.