In many cases, such as liver or kidney insufficiency, or various acute complications of diabetes, metformin should not be taken. Specific common contraindications are listed below: 1. severe renal insufficiency, or acute conditions that may affect renal function, such as severe infections and shock. 2. Various diseases that may lead to hypoxia. Such as cardiac insufficiency, respiratory infection, trauma, surgery. 3. In acute complications of diabetes mellitus, such as ketoacidosis, hyperglycemic hyperosmolar state, lactic acidosis. 4. In case of allergy to metformin or excipients in the product. 5. Severe hepatic insufficiency. Such as alcoholic liver disease or when transaminases are significantly elevated. 6.Metformin is generally not recommended for children under 10 years of age. It is recommended that Metformin be taken under the supervision of a doctor and not on its own.