There are 3 clinical types of genital HSV infection: 1. Primary infection: The patient first presents with foci of genital HSV infection and antibodies to HSV-1 and HSV-2 are not yet present in the body. 2. Non-primary initial infection: the patient presents with a lesion of genital HSV infection for the first time, but antibodies to HSV are already present in the body that are different from those acquired from this lesion of genital HSV infection. For example, HSV-2 is detected from a genital lesion in a patient who already has HSV-1 antibodies and no HSV-2 antibodies, which is the most common situation, especially in patients with a history of orofacial herpes; HSV-1 is detected from a genital lesion in a patient who already has HSV-2 antibodies and no HSV-1 antibodies, which is less common. 3. Recurrent infection: The type of HSV detected in the genital lesions is the same as the type of antibody already present in the serum. Most recurrent genital herpes cases are caused by HSV-2. Most genital herpes infections are transmitted through people who do not know they have the infection, or through asymptomatic people. specific antibodies to HSV are usually produced within 12 weeks of infection and can be present for life. II. Genital HSV infection during pregnancy: Accurate classification of infection during pregnancy is particularly important. The virus can be excreted in the absence of symptoms and foci in the mother. HSV-2 infection has a higher rate of viral excretion compared to HSV-1 infection. Women with primary HSV infection can become infected intrauterine through the placenta or the cervix (via the chorionic amnion) and intrauterine infection can lead to miscarriage, congenital malformations, preterm delivery and/or intrauterine growth restriction. Recurrent HSV infection, on the other hand, does not lead to these adverse pregnancy outcomes. Intrauterine infection should be considered when the newborn becomes infected with HSV very early despite a cesarean section and intact membranes before delivery. 1. Congenital (intrauterine) infection: Intrauterine or congenital HSV is rare and mostly originates from maternal viremia due to initial HSV infection during gestation or upstream infection from maternal viremia due to initial HSV infection during gestation. Intrauterine infection due to initial maternal HSV infection in pregnancy and viremia causes placental infarction, necrotizing, calcific corditis, plasmacytic metritis, lymphoplasmacytic chorioamnionitis, fetal edema, and intrauterine death. Those who survive intrauterine HSV infection may present with a characteristic triad of signs: skin blisters, ulcers or scarring; eye damage; and severe CNS manifestations (including microcephaly or hydrocephalic anencephaly). 2. Neonatal HSV infection: HSV transmission to newborns usually occurs during labor and delivery and is caused by direct contact of the newborn with the virus discharged from the infected site (cervical, vaginal, vulva, perianal). (1) If a newborn acquires HSV infection during the perinatal period, most of her mothers do not have a clinically significant history of genital herpes. (2), If a woman develops primary genital HSV infection near the time of delivery, then the newborn is at highest risk for HSV infection. (3) The risk of neonatal infection is slightly lower in women with non-primary primary genital infections. (4), The risk was substantially lower in women with recurrent HSV infection. Two case series included women who underwent viral culture at the time of labor and delivery and were found to be positive, and their neonatal infection rates were: primary infection: 2/5 (40%) and 4/9 (44%); non-primary primary genital infection: 4/13 (31%) and 4/17 (24%); recurrent infection: 1/34 (3%) and 2/151 (1.3%) .