According to the pharmacokinetics of cephalosporin antibiotics, it is generally necessary to hang the second time at an interval of 8 to 12 hours, in accordance with renal function, can be appropriately extended. Cephalosporin antibiotics mechanism of action is the system of bacterial septum and cell wall synthesis, affecting the bacterial cell division and growth, and finally dissolution and death, including a wide variety of cephalosporin, from the first generation of cephalosporin to the current fifth generation of cephalosporin, different types of cephalosporin, blood elimination of the half-life is different, the effective concentration is also different. At present, the clinical, often used cephalosporin antibiotics, normal adult half-life ranging from 1 hour to 3 hours, some children and the elderly or renal insufficiency, the half-life can be prolonged. According to relevant clinical trials, the effective concentration of cephalosporin antibiotics can generally be maintained for about 8 hours, within 8 to 12 hours, repeat medication, no drug accumulation, the current recommended use of cephalosporin antibiotics: according to the condition, choose to give the drug 2 to 3 times a day, i.e., an interval of 8 to 12 hours of medication. The actual use of cephalosporins should be adjusted according to the patient’s condition. The use of cephalosporin antibiotics, there are strict indications for the use of medication, and may be allergic reactions, gastrointestinal reactions and other adverse reactions, it is recommended to seek medical attention, under the guidance of a physician.