Swollen ankles after running can be relieved by proper rest, physical therapy and taking anti-inflammatory and analgesic drugs. 1. Appropriate rest: patients may not exercise for a long time and suddenly start to exercise, or do not warm up sufficiently before running, caused by the discomfort of the ankle joints, resulting in running ankle swelling and pain, through appropriate rest, reduce the amount of activity on the local stimulation, which can help relieve pain. 2. Physiotherapy: If the patient has obvious symptoms, low-frequency electrotherapy, short-wave thermotherapy, no infrared light therapy can improve the circulation, promote the absorption of inflammatory mediators, to eliminate the role of running ankle swelling and pain. 3. Taking anti-inflammatory and analgesic drugs: patients can take ibuprofen, celecoxib and other drugs under the guidance of the doctor to relieve pain, which is prohibited for those who are allergic to this kind of drugs and other non-steroidal anti-inflammatory drugs. Swollen ankles after running may also be lower extremity venous thrombosis, lymphatic reflux disorders or chronic nephritis and other problems, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor’s treatment.