Aspirin has been reported to work by inhibiting the function of platelets in the blood. With more than 80% of platelet function inhibited in the body, cardiovascular diseases can be prevented. Every day the human body has about
1/10 platelets are re-generated, so taking the drug once a day only needs to suppress the newly generated, functional platelets to maintain more than 90% of the platelets from functioning. For these reasons, aspirin only needs to be taken once a day. So, when is the best time to take this once? Opinions are divided as to whether it is better to take aspirin in the morning or in the evening. Most opinions prefer to take it in the morning. Because from the human biological clock, 6:00~10:00 in the morning, the blood viscosity is thicker.
At 6:00 am to 10:00 am, the blood viscosity is high, and the blood pressure and heart rate are also high, which is the time when cardiovascular and cerebrovascular accidents are more likely to occur. Therefore, for the purpose of treatment and prevention of cardiovascular diseases, aspirin should be taken at 7:00~8:00 am.
Therefore, for the treatment and prevention of cardiovascular disease, aspirin should be taken between 7:00 and 8:00 am. Recently, the American College of Chest Physicians (ACCP) published a report on antithrombotic and thrombolytic therapy.
The ACCP evidence-based guidelines for antithrombotic and thrombolytic therapy state that aspirin is best taken after breakfast for the prevention of myocardial infarction, stroke, and vascular death, and that aspirin enteric tablets are the best dosage form. One view is that because the body is less active at night, blood is viscous, blood flow slows down, and platelets tend to aggregate, so taking the drug in the evening may provide better efficacy. For most patients, because of the short peak time and half-life of regular aspirin enteric tablets, it is more appropriate to take them in the morning; for patients taking aspirin extended-release tablets, it is more appropriate to take them at night because of the long peak time and half-life.