Nasopharyngeal cancer skull base bone destruction refers to nasopharyngeal cancer patients with cancer cells infiltrating and destroying skull base bone, which belongs to locally advanced or late stage. When some nasopharyngeal cancer patients go to the doctor for imaging examination, it is found that the cancer cells infiltrate and destroy the skull base bone, which will be expressed as nasopharyngeal cancer skull base bone destruction. Usually, this phenomenon belongs to the advanced stage of the disease, and nasopharyngeal cancer patients are also prone to hearing loss, nasal congestion, blood in snot, headache, facial numbness, diplopia, drooping eyelids, hoarse voice and other symptoms. For nasopharyngeal cancer patients with bone destruction at the base of the skull, they can be treated by molecular targeted therapy, immunotherapy, radiotherapy, chemotherapy and other modalities in order to control the invasion of cancer cells to the bone and alleviate the uncomfortable symptoms caused by the disease. In the advanced stage of nasopharyngeal cancer, the cancer cells not only metastasize to the brain, but also easily metastasize to the lungs, liver and other parts of the body, so the patients need to consult doctors regularly for review. It is suggested that people with nasopharyngeal cancer with bone destruction at the base of the skull should cooperate with doctors to take treatment measures according to their own conditions. They should pay attention to rest, maintain physical and mental happiness and have balanced intake of nutrients.