Apply film to cell phone to prevent screen scratching; apply film to gastrointestinal tract to protect mucosa from damage. Gastric mucosal protective agents such as aluminum thioglycollate, magnesium aluminum carbonate, bismuth potassium citrate, etc., can quickly attach to the gastric mucosa and the surface of the lesion after oral administration, forming a protective film, so that the local no longer be attacked by gastric acid, digestive enzymes, drugs, etc., to play a role in isolation, is widely used in the treatment of gastric and duodenal ulcers. Affected by this mechanism of action, this type of medicine is most afraid of the following conditions.
1. Wrong time
Aluminum thioglycollate tablets: take them 1 hour before meals and after chewing before bedtime.
Bismuth potassium citrate: taken half an hour before meals and at bedtime. This drug is not an antibiotic class of drugs, but has a clear killing effect on Helicobacter pylori (Hp).
Magnesium aluminum carbonate: 1-2 hours after meals and before bedtime or stomach discomfort chewed and taken. Magnesium aluminum carbonate is both a gastric mucosa protective agent, but also an antacid agent, can buffer stomach acid, to ensure that the optimal pH in the stomach. therefore, this drug should be taken after meals.
2.Posture is not right
When taking gastric mucosal protective agent, pay attention to the posture of taking the drug.
When standing, because of the short contact time between the drug and the ulcer surface, the effect of the drug cannot be fully developed, so lying down for half an hour after taking the drug can slow down the emptying of the drug, prolong the local action of the drug and improve the efficacy.
3.Drink water immediately
When taking gastric mucosal protective agent, only a small amount of warm water to send down the drug, should not drink too much water within half an hour. Otherwise, the newly formed protective film of the drug may be washed away, making its protective effect weakened.
If you want to drink water, you should wait for the protective film to stabilize or reach the time of drug action after half an hour of taking the drug, and then drink in moderation.
Before and after taking gastric mucosal protective agent half a small also should not take milk, carbonated drinks, coffee and tea, etc..
4.Mixing drugs
Gastric mucosal protector should not be taken before or within 1 hour after taking other drugs.
Gastric mucosal protective agent, can reduce the absorption of H2 receptor antagonist (cimetidine, ranitidine, famotidine) acid suppressant; H2 receptor antagonist, can reduce the efficacy of gastric mucosal protective agent.
Gastric mucosal protective agents contain metal ions such as aluminum, bismuth and magnesium, which can form complexes with tetracyclines and quinolones and reduce their absorption in the digestive tract.
Gastric mucosal protective agents can also reduce the absorption of digoxin, coumarin anticoagulants, iron preparations, deoxycholic acid and other drugs.
Gastric mucosal protective agent and enteric tablets taken together can make enteric tablets dissolve faster, should not be used together.
5.The course of treatment is too long
Bismuth potassium citrate course of 4-8 weeks, long-term high dose may lead to bismuth encephalopathy, may also cause nephrotoxicity.
Aluminum thiosulfate, aluminum magnesium carbonate should not be taken continuously for more than 8 weeks. Long-term use, aluminum accumulation and aluminum moderate can occur, the emergence of osteochondrosis and encephalopathy, etc..
In addition, because the gastric mucosa protective agent can interfere with the absorption of fat-soluble vitamins in food (especially vitamin A), long-term use can lead to fat-soluble vitamin deficiency.