Etoricoxib and Celecoxib are both painkillers. Ettokoxib and Celecoxib are both non-steroidal anti-inflammatory drugs, and are cyclooxygenase-2 inhibitors, in terms of drug mechanism, indications and other aspects of the roughly the same, both through the selective inhibition of the human body within the cyclooxygenase-2 to play the role of antipyretic, analgesic, compared with other non-steroidal anti-inflammatory drugs, Ettokoxib and Celecoxib to the gastrointestinal tract produces a relatively small irritability. Both drugs can be used to relieve symptoms of pain and fever caused by diseases such as osteoarthritis and gout. Common adverse drug reactions to etoricoxib are dyspepsia, nausea, and nasopharyngitis, while common adverse drug reactions to celecoxib are gastrointestinal discomfort, upper respiratory tract infections, and skin rash. Etoricoxib and Celecoxib are contraindicated in patients with contraindications to both drugs. Celecoxib should not be used in patients with known hypersensitivity to sulfa. Note that both etoricoxib and celecoxib can cause new-onset hypertension or exacerbate pre-existing hypertension, either of which can lead to an increased incidence of cardiovascular events. Both etoricoxib and celecoxib should be used under the supervision of a physician, and it is recommended that patients who need to take these two drugs go to the relevant departments of regular hospitals for detailed consultation.