Mannitol and dexamethasone can be used in patients with lumbar disc herniation, but must be strictly followed by the doctor’s instructions. In the acute stage of lumbar disc herniation, the herniated material causes edema of the surrounding soft tissues and nerve compression symptoms, which are mainly manifested as acute onset of severe lumbago, radiating leg pain, and in severe cases, sudden paralysis or weakness and loss of sensation of one or both lower limbs, or even urinary and fecal incontinence, which is clinically known as acute cauda equina syndrome. Mannitol can promote circulation, reduce lumbar disc herniation acute tissue edema, reduce the compression of the nerve root, has a certain diuretic effect, generally clinically based on intravenous infusion. Dexamethasone class can reduce local nerve root inflammation, relieve the symptoms of acute phase lumbago and leg pain. Mannitol and dexamethasone both have adverse reactions, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication, so as to avoid adverse reactions.