Amoxicillin and ibuprofen can be taken together. Amoxicillin and ibuprofen are both commonly used drugs. Amoxicillin, also known as hydroxybenzyl penicillin, belongs to the penicillin class of antibiotics and can treat bacterial infections in the respiratory tract, urinary tract, and soft tissues of the skin; ibuprofen is an antipyretic and anti-inflammatory drug with fewer side effects and better safety, and is effective for fever, headache, sore throat, and muscle aches that occur when you have a cold. Both medicines can be used by adults and children. For example, if a child has a cold, sore throat, high fever, headache, sore muscles all over the body, and the doctor finds a combined bacterial infection after examination, and the child is not allergic to penicillin, he or she can take amoxicillin and ibuprofen together to treat it. Amoxicillin is responsible for anti-inflammatory and antiseptic, while ibuprofen is responsible for reducing fever and relieving pain.