Herberden’s nodes are a clinical manifestation of osteoarthritis of the fingers, which occurs in the distal phalangeal joints with bony hypertrophy. The main manifestations of Herberden’s nodes are bony hypertrophy of the distal phalangeal joints, flexion deformity, etc. Usually, medication and surgery are available, which need to be selected according to their own situation. First, drug treatment: 1, sodium hyaluronate: the main component of synovial fluid in the joint cavity, one of the components of cartilage matrix, plays a lubricating role in the joints to reduce the friction between the tissues, the injection of synovial fluid into the joint cavity can improve the inflammatory response of the tissues, enhance the lubrication function of the joint fluid, protect the articular cartilage, promote the healing and regeneration of the articular cartilage, alleviate the pain, and increase the mobility of the joints; 2, glucosamine Glucosamine can block the pathogenesis of osteoarthritis, promote the synthesis of chondrocytes with normal structure of proteoglycans, and inhibit the enzyme production of damaged tissues and cartilage, reduce the damage of chondrocytes, in order to improve the joint activity, alleviate the pain of the joints, and slow down the course of osteoarthritis; 3, non-steroidal anti-inflammatory drugs: non-steroidal anti-inflammatory drugs can inhibit cyclo-oxygenase and the synthesis of prostaglandins, to counteract inflammatory reaction, relieve Joint edema, pain, commonly used drugs are topical diclofenac diethylamide emulsion, as well as internal aspirin, ibuprofen and so on. Surgery: If some patients are not treated in time, and symptoms such as flexion deformity and activity limitation occur, they can consider choosing artificial joint replacement after relieving the pain to restore the joint function in combination with their own situation.