Hormones mostly refer to adrenal glucocorticoids, which mainly decompose the body’s fat metabolism and will cause the centripetal distribution of fat in the patient’s body. Long-term use of glucocorticoid drugs can cause obesity for the following reasons: 1, can promote fat synthesis, make fat redistribution, so long-term use of glucocorticoid patients, appear centripetal obesity, can also appear typical symptoms such as full-moon face, buffalo back; 2, due to the rise in hormone levels, strengthen the decomposition of sugar, causing an increase in blood sugar, and at the same time, it also leads to the rise of insulin, which in turn leads to fat synthesis and 3. Hormones have a greater impact on the stomach, prompting an increase in appetite and an inability to control the desire to eat, leading to an excessive intake of total calories and causing obesity; 4. A more common side effect of hormone application is that it can cause water and sodium retention in patients, leading to edema and making them look more obese than before. If only for occasional use of hormone drugs, generally will not cause obesity, long-term use caused by obesity when hormone drugs suspended, through exercise, diet regulation for weight loss, can restore weight, patients do not have to worry too much.